Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration

Redmond Lab

David Redmond, PhD · Assistant Professor of Computational Biology

We work at the interface of computational and wet lab biology. We run the experiments and we build the methods, and neither half is a service function for the other.

We use high-dimensional and single-cell measurement, across transcriptome, chromatin, protein and tissue space, together with functional assays at the bench, to study two things: how transcriptional regulation establishes and maintains cell identity, and how immune cells and the parenchyma and stroma around them shape each other.

We work on those questions in development, in stem cell and iPS-derived models, in inflammation, and in ageing and regeneration.

In practice that means building atlases of cell state across tissues, working out which regulators actually set identity, and testing whether they are enough to move a cell from one state to another. We perturb systems rather than just watching them, and we care where things happen in tissue, not only what is there. Wherever we can, we check a conclusion from more than one direction, at the bench and against independent human data. A result that only holds up in cross-validation is not really a result.